Clinical Outcomes & References

Clinically proven.

The SPRINT PNS System has been studied extensively for low back pain, shoulder pain, post-amputation pain, and chronic and acute post-operative pain, and is cleared for use up to 60 days.

SPRINT system-related peer-reviewed publications, presentations, and collected data.

• Gilmore CA, Desai MJ, Hopkins TJ, Li S, DePalma MJ, Deer TR, Grace W, Burgher AH, Sayal PK, Amirdelfan K, Cohen SP, McGee MJ, Boggs JW, Treatment of Chronic Axial Back Pain with 60-day Percutaneous Medial Branch PNS: Primary Endpoint Results from a Prospective, Multicenter Study, PAIN Practice, July 2021.
• Ilfeld BM, Plunkett A, Vijjeswarapu AM, Hackworth R, Dhanjal S, Turan A, Cohen SP, Eisenach JC, Griffith S, Hanling S, Sessler DI, Mascha EJ, Yang D, Boggs JW, Wongsarnpigoon A, Gelfand H Percutaneous, Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Pain: A Randomized, Sham-controlled Pilot Study, Anesthesiology, April 2021.
• Deer TR, Eldabe S, Falowski SM, Huntoon MA, Staats PS, Cassar IR, Crosby ND, Boggs JW. Peripherally-Induced Reconditioning of the CNS: Proposed Mechanisms for Sustained Relief Following 60-Day Percutaneous PNS Treatment, Journal of Pain Research, 12 March 2021 Volume 2021:14 Pages 721-736.
• Deer TR, Gilmore CA, Desai MJ, Li SC, DePalma MJ, Hopkins TJ, Burgher AH, Spinner DA, Cohen SP, McGee MJ, Boggs JW. Percutaneous Peripheral Nerve Stimulation of the Medial Branch Nerves for the Treatment of Chronic Axial Back Pain in Patients After Radiofrequency Ablation, Pain Medicine, 2021; pnaa432
• Gulati A, Desai MJ, Rosenow JM, Cohen SP, Crosby ND, Boggs JW. Sustained Pain Relief Following 60-Day Percutaneous PNS in Majority of Patients: Review of Clinical Evidence, 2021. View Poster Here.
• Gulati A, Deer TR, Ottestad E, Erdek M, Crosby ND, Stultz MR, Staats P. Patient Preferences Among Various Interventional Pain Management Treatment Options, 2021. View Poster Here.
• Gulati A, Desai MJ, Rosenow JM, Cohen SP, Crosby ND, Boggs JW. A Review of Clinical Evidence for Percutaneous Peripheral Nerve Stimulation Demonstrating Sustained Relief of Chronic Pain in a Majority of Subjects. As presented at 2020 American Society for Pain and Neuroscience (ASPN). View Poster here.
• Gilmore, C, Kapural, L, Hopkins T, Desai M, Li S, DePalma M, Deer TR, Burgher A, McGee M, Boggs J. Reductions in Opioid Consumption Reported among Chronic Low Back Pain Patients Following Percutaneous Peripheral Nerve Stimulation (PNS) of the Medial Branch Nerves for up to 60 Days. As presented at American Society of Regional Anesthesia and Pain Medicine November 2019.
• Gilmore CA, Kapural L, McGee M, Boggs JW. Percutaneous Peripheral Nerve Stimulation for Chronic Low Back Pain: Prospective Case Series with One Year of Sustained Relief following Short‐term Implant. Pain Pract. 2019 Nov 6.
• Gilmore CA, Ilfeld BM, Rosenow JM, Li S, Desai MJ, Hunter CW, Rauck RL, Nader A, Mak J, Cohen SP, Crosby ND, Boggs JW. Percutaneous 60-day Peripheral Nerve Stimulation Implant Provides Sustained Relief of Chronic Pain Following Amputation: 12-month Follow-Up of a Randomized, Double-Blind, Placebo-Controlled Trial. Regional Anesthesia and Pain Medicine, 2020; 45:44-51. View Poster Here. 
• Gilmore CA, Kapural L, McGee M, Boggs JW. Percutaneous Peripheral Nerve Stimulation for Chronic Low Back Pain: Prospective Case Series with One Year of Sustained Relief following Short‐term Implant. Pain Pract. 2019
• Cohen S, Gilmore C, Kapural L, Hopkins T, Desai M, DePalma M, Li S, Burgher A, Deer T, Plunkett T, McGee M, Boggs J. Reductions in Opioid Consumption with Percutaneous Medial Branch Peripheral Nerve Stimulation for Chronic Low Back Pain as presented at the Military Health Research Symposium August 21, 2019, Kissimmee, FL.
• Ilfeld BM, Ball ST, Cohen SP, Hanling SR, Fowler IM, Wongsarnpigoon A, Boggs JW. Percutaneous Peripheral Nerve Stimulation to Control Postoperative Pain, Decrease Opioid Use, and Accelerate Functional Recovery Following Orthopedic Trauma. Mil Med. 2019 Mar 1;184(Supplement_1):557-564.
• Physician Survey Data from PNS Leadership Forum, Scottsdale AZ, December 2019. Data on file SPR Therapeutics.
• Patient Preference Survey, 2019. Data on file SPR Therapeutics.
• Cohen SP, Gilmore CA, Kapural L, Hanling S, Plunkett A, McGee MJ, Boggs JW. Percutaneous Peripheral Nerve Stimulation for Pain Reduction and Improvements in Functional Outcomes in Chronic Low Back Pain. Mil Med. 2019 Mar 1;184(Supplement_1):537-541.
• Cohen SP, Gilmore CA, Rauck RL, Lester DD, Trainer RJ, Phan T, Kapural L, North JM, Crosby ND, Boggs JW. Percutaneous Peripheral Nerve Stimulation for the Treatment of Chronic Pain Following Amputation. Military Medicine, 2019:10.1093/milmed/usz114.
• Christopher A. Gilmore, MD et al, Percutaneous Peripheral Nerve Stimulation for the Treatment of Chronic Neuropathic Post-Amputation Pain: A Multi-Center Randomized Placebo-Controlled Trial. Regional Anesthesia and Pain Medicine, 2019.
• Ilfeld, B.M., J.J.t. Finneran, R.A. Gabriel, E.T. Said, P.L. Nguyen, W.B. Abramson, B. Khatibi, J.F. Sztain, M.W. Swisher, P. Jaeger, D.C. Covey, M.J. Meunier, E.R. Hentzen, and C.M. Robertson, Ultrasound-guided percutaneous peripheral nerve stimulation: neuromodulation of the suprascapular nerve and brachial plexus for postoperative analgesia following ambulatory rotator cuff repair. A proof-of-concept study. Reg Anesth Pain Med, 2019.
• Wilson, Richard D., et al. Fully Implantable Peripheral Nerve Stimulation for Hemiplegic Shoulder Pain: A Multi‐Site Case Series With Two‐Year Follow‐Up. Neuromodulation: Technology at the Neural Interface 21.3 (2018): 290-295.
• Gilmore CA, Kapural L, McGee MJ, Boggs JW. Percutaneous Peripheral Nerve Stimulation (PNS) for the Treatment of Chronic Low Back Pain Provides Sustained Relief. Neuromodulation. 2018 Oct 3.
• Ilfeld, Brian M., et al., Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: Neuromodulation of the Sciatic Nerve for Postoperative Analgesia Following Ambulatory Foot Surgery, a Proof-of-Concept Study. Regional Anesthesia and Pain Medicine 2018. 43(6): p. 580–589.
• Ilfeld B.M., Ball S.T., Gabriel R.A., Sztain J.F., Monahan A.M., Abramson W.B., Khatibi B., Said E.T., Parekh J., Grant S.A., Wongsarnpigoon A., Boggs J.W. 2018. A Feasibility Study of Percutaneous Peripheral Nerve Stimulation for the Treatment of Postoperative Pain Following Total Knee Arthroplasty. Neuromodulation; 22 (5), 653-660
• Shellock, FG, Zare A, Ilfeld BM, Chae J, Strother, RB (2018).Vitro Magnetic Resonance Imaging Evaluation of Fragmented, Open-Coil, Percutaneous Peripheral Nerve Stimulation Leads. Neuromodulation Volume 21, Issue 3, 276-283.
• Gilmore, C.A., Kapural, L, McGee, M.J., Boggs, J.W. (2018). Minimally invasive percutaneous peripheral nerve stimulation (PNS) reduces pain and disability in chronic low back pain. World Congress on Regional Anesthesia and Pain Medicine (ASRA), 2018.
• Gilmore C.A., Ilfeld B.M., Rosenow J.M., Li S., Desai M.J., Hunter C.W., Nader A., Mak J., Rauck R.L., Kapural L., Crosby N.D., Boggs J.W. (2018). Percutaneous peripheral nerve stimulation (PNS) for the treatment of chronic neuropathic post-amputation pain: Initial results from a multicenter, randomized, placebo-controlled study. Napa Pain Conference.
• Staats, P. Neuromodulation as an Alternative to Opioid in the Evolving Health Care Crisis – A Supplement to Pain Medicine News (2017)
• lIfeld, B. M., et al., Ultrasound-guided percutaneous peripheral nerve stimulation for analgesia following total knee arthroplasty Journal of Orthopaedic Surgery and Research (2017)
• Kapural L, Gilmore CA, Chae J, et al. Percutaneous Peripheral Nerve Stimulation for the Treatment of Chronic Low Back Pain: Two Clinical Case Reports of Sustained Pain Relief. Pain Pract. 2017.
• Ilfeld, B.M., Gilmore, C.A., Grant, S.A., Bolognesi, M. P., Del Gaizo, D.J., Wongsarnpigoon, A., & Boggs, J.W. (2017). Ultrasound-guided percutaneous peripheral nerve stimulation for analgesia following total knee arthroplasty: a prospective feasibility study. Journal of orthopaedic surgery and research, 12(1), 4.
• Ilfeld, B.M. and S.A. Grant, Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation for Postoperative Analgesia: Could Neurostimulation Replace Continuous Peripheral Nerve Blocks? Reg Anesth Pain Med, 2016.
• Ilfeld, B. M., et al., Infection Rates of Electrical Leads Used for Percutaneous Neurostimulation of the Peripheral Nervous System. Pain Pract. (2016)
• Ilfeld, B.M., Grant, S.A., Gilmore, C.A., Chae, J., Wilson, R.D., Wongsarnpigoon, A., & Boggs, J.W. (2016). Neurostimulation for Postsurgical Analgesia: A Novel System Enabling Ultrasound-guided Percutaneous Peripheral Nerve Stimulation. Pain Practice, 17(7), 892-901.
• Nguyen, V.Q., et al., Fully implantable peripheral nerve stimulation for the treatment of hemiplegic shoulder pain: a case report. Am J Phys Med Rehabil, 2015. 94(2): p. 146-53.
• Rauck, R.L., Cohen, S.P., Gilmore, C.A., North, J.M., Kapural, L., Zang, R.H., & Boggs, J.W. (2014). Treatment of post-amputation pain with peripheral nerve stimulation. Neuromodulation: Technology at the Neural Interface, 17(2), 188-197.
• Wilson, R.D., Harris, M. A., Gunzler, D.D., Bennett, M.E., & Chae, J. (2014). Percutaneous peripheral nerve stimulation for chronic pain in subacromial impingement syndrome: a case series. Neuromodulation: Technology at the Neural Interface, 17(8), 771-776.
• Wilson, R.D., Gunzler, D.D., Bennett, M.E., & Chae, J. (2014). Peripheral nerve stimulation compared with usual care for pain relief of hemiplegic shoulder pain: a randomized controlled trial. American journal of physical medicine & rehabilitation/Association of Academic Physiatrists, 93(1), 17.
• Chae, J., Wilson, R.D., Bennett, M.E., Lechman, T. E., & Stager, K.W. (2013). Single-lead percutaneous peripheral nerve stimulation for the treatment of hemiplegic shoulder pain: a case series. Pain practice, 13(1), 59-67.
• Rauck, R.L., et al., Peripheral nerve stimulation for the treatment of post-amputation pain–a case report. Pain practice: the official journal of World Institute of Pain, 2012. 12(8): p. 649-55.
• Stolzenberg, D., G. Siu, and E. Cruz, Current and future interventions for glenohumeral subluxation in hemiplegia secondary to stroke. Top Stroke Rehabil, 2012. 19(5): p. 444-56.
• Wilson, R.D., et al., Single-lead percutaneous peripheral nerve stimulation for the treatment of hemiplegic shoulder pain: a case report. Arch Phys Med Rehabil, 2011. 92(5): p. 837-40.
• Chae, J., et al., Intramuscular electrical stimulation for shoulder pain in hemiplegia: does time from stroke onset predict treatment success? Neurorehabil Neural Repair, 2007. 21(6): p. 561-7.
• Chae, J., David, T.Y., Walker, M.E., Kirsteins, A., Elovic, E.P., Flanagan, S.R., & Fang, Z.P. (2005) Intramuscular electrical stimulation for hemiplegic shoulder pain: a 12-month follow-up of a multiple-center, randomized clinical trial. American journal of physical medicine & rehabilitation, 84(11), 832-842.
• Renzenbrink, G.J. and I.J. MJ, Percutaneous neuromuscular electrical stimulation (P-NMES) for treating shoulder pain in chronic hemiplegia. Effects on shoulder pain and quality of life. Clin Rehabil, 2004. 18(4): p. 359-65.
• Yu, D.T., et al., Intramuscular neuromuscular electric stimulation for poststroke shoulder pain: a multicenter randomized clinical trial. Arch Phys Med Rehabil, 2004. 85(5): p. 695-704.
• Chae, J., D. Yu, and M. Walker, Percutaneous, intramuscular neuromuscular electrical stimulation for the treatment of shoulder subluxation and pain in chronic hemiplegia: a case report. Am J Phys Med Rehabil, 2001. 80(4): p. 296-301.
• Yu, D.T., Chae, J., Walker, M.E., & Fang, Z. P. (2001). Percutaneous intramuscular neuromuscular electric stimulation for the treatment of shoulder subluxation and pain in patients with chronic hemiplegia: a pilot study. Archives of physical medicine and rehabilitation, 82(1), 20-25.