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Minimally Invasive. Highly Impressive.

Proven clinical results

The SPRINT® PNS System has been studied extensively in chronic neuropathic pain, chronic back pain and acute post-surgical pain. SPR Therapeutics continues to support research across a wide spectrum of potential uses.

Summary of SPRINT PNS Clinical Outcomes

Subjects receiving the SPRINT therapy have experienced significant pain relief. While the SPRINT system is indicated for use up to 60 days, subjects have experienced lasting clinical benefits after the short-term therapy.

Significant Pain Relief

Significant pain relief

74% of patients treated with the SPRINT system report ≥50% reduction in pain intensity or pain interference.(1,5,10-13,15,18,22,23,26)

Sustained Pain Relief

Sustained pain relief

73% of patients report significantly less pain even after the lead is withdrawn.(1,5,10-13,22,23)

SPRINT system-related peer-reviewed publications and presentations

  1. Yu, D.T., Chae, J., Walker, M.E., & Fang, Z. P. (2001). Percutaneous intramuscular neuromuscular electric stimulation for the treatment of shoulder subluxation and pain in patients with chronic hemiplegia: a pilot study. Archives of physical medicine and rehabilitation, 82(1), 20-25.
  2. Chae, J., D. Yu, and M. Walker, Percutaneous, intramuscular neuromuscular electrical stimulation for the treatment of shoulder subluxation and pain in chronic hemiplegia: a case report. Am J Phys Med Rehabil, 2001. 80(4): p. 296-301.
  3. Yu, D.T., et al., Intramuscular neuromuscular electric stimulation for poststroke shoulder pain: a multicenter randomized clinical trial. Arch Phys Med Rehabil, 2004. 85(5): p. 695-704.
  4. Renzenbrink, G.J. and I.J. MJ, Percutaneous neuromuscular electrical stimulation (P-NMES) for treating shoulder pain in chronic hemiplegia. Effects on shoulder pain and quality of life. Clin Rehabil, 2004. 18(4): p. 359-65.
  5. Chae, J., David, T.Y., Walker, M.E., Kirsteins, A., Elovic, E.P., Flanagan, S.R., & Fang, Z.P. (2005) Intramuscular electrical stimulation for hemiplegic shoulder pain: a 12-month follow-up of a multiple-center, randomized clinical trial. American journal of physical medicine & rehabilitation, 84(11), 832-842.
  6. Chae, J., et al., Intramuscular electrical stimulation for shoulder pain in hemiplegia: does time from stroke onset predict treatment success? Neurorehabil Neural Repair, 2007. 21(6): p. 561-7.
  7. Wilson, R.D., et al., Single-lead percutaneous peripheral nerve stimulation for the treatment of hemiplegic shoulder pain: a case report. Arch Phys Med Rehabil, 2011. 92(5): p. 837-40.
  8. Stolzenberg, D., G. Siu, and E. Cruz, Current and future interventions for glenohumeral subluxation in hemiplegia secondary to stroke. Top Stroke Rehabil, 2012. 19(5): p. 444-56.
  9. Rauck, R.L., et al., Peripheral nerve stimulation for the treatment of post-amputation pain–a case report. Pain practice: the official journal of World Institute of Pain, 2012. 12(8): p. 649-55.
  10. Chae, J., Wilson, R.D., Bennett, M.E., Lechman, T. E., & Stager, K.W. (2013). Single-lead percutaneous peripheral nerve stimulation for the treatment of hemiplegic shoulder pain: a case series. Pain practice, 13(1), 59-67.
  11. Wilson, R.D., Gunzler, D.D., Bennett, M.E., & Chae, J. (2014). Peripheral nerve stimulation compared with usual care for pain relief of hemiplegic shoulder pain: a randomized controlled trial. American journal of physical medicine & rehabilitation/Association of Academic Physiatrists, 93(1), 17.
  12. Wilson, R.D., Harris, M. A., Gunzler, D.D., Bennett, M.E., & Chae, J. (2014). Percutaneous peripheral nerve stimulation for chronic pain in subacromial impingement syndrome: a case series. Neuromodulation: Technology at the Neural Interface, 17(8), 771-776.
  13. Rauck, R.L., Cohen, S.P., Gilmore, C.A., North, J.M., Kapural, L., Zang, R.H., & Boggs, J.W. (2014). Treatment of post-amputation pain with peripheral nerve stimulation. Neuromodulation: Technology at the Neural Interface, 17(2), 188-197.
  14. Nguyen, V.Q., et al., Fully implantable peripheral nerve stimulation for the treatment of hemiplegic shoulder pain: a case report. Am J Phys Med Rehabil, 2015. 94(2): p. 146-53.
  15. Ilfeld, B.M., Grant, S.A., Gilmore, C.A., Chae, J., Wilson, R.D., Wongsarnpigoon, A., & Boggs, J.W. (2016). Neurostimulation for Postsurgical Analgesia: A Novel System Enabling Ultrasound-guided Percutaneous Peripheral Nerve Stimulation. Pain Practice, 17(7), 892-901.
  16. Ilfeld, B. M., et al., Infection Rates of Electrical Leads Used for Percutaneous Neurostimulation of the Peripheral Nervous System. Pain Pract. (2016)
  17. Ilfeld, B.M. and S.A. Grant, Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation for Postoperative Analgesia: Could Neurostimulation Replace Continuous Peripheral Nerve Blocks? Reg Anesth Pain Med, 2016.
  18. Ilfeld, B.M., Gilmore, C.A., Grant, S.A., Bolognesi, M. P., Del Gaizo, D.J., Wongsarnpigoon, A., & Boggs, J.W. (2017). Ultrasound-guided percutaneous peripheral nerve stimulation for analgesia following total knee arthroplasty: a prospective feasibility study.  Journal of orthopaedic surgery and research, 12(1), 4.
  19. Kapural L, Gilmore CA, Chae J, et al. Percutaneous Peripheral Nerve Stimulation for the Treatment of Chronic Low Back Pain: Two Clinical Case Reports of Sustained Pain Relief. Pain Pract. 2017. doi: 10.1111/papr.12571
  20. lIfeld, B. M., et al., Ultrasound-guided percutaneous peripheral nerve stimulation for analgesia following total knee arthroplasty  Journal of Orthopaedic Surgery and Research (2017)
  21. Staats, P. Neuromodulation as an Alternative to Opioid in the Evolving Health Care CrisisA Supplement to Pain Medicine News (2017)
  22. Gilmore C.A., Ilfeld B.M., Rosenow J.M., Li S., Desai M.J., Hunter C.W., Nader A., Mak J., Rauck R.L., Kapural L., Crosby N.D., Boggs J.W. (2018). Percutaneous peripheral nerve stimulation (PNS) for the treatment of chronic neuropathic post-amputation pain: Initial results from a multicenter, randomized, placebo-controlled study. Napa Pain Conference.
  23. Gilmore, C.A., Kapural, L, McGee, M.J., Boggs, J.W. (2018). Minimally invasive percutaneous peripheral nerve stimulation (PNS) reduces pain and disability in chronic low back pain. World Congress on Regional Anesthesia and Pain Medicine (ASRA), 2018.
  24. Shellock, FG, Zare A, Ilfeld BM, Chae J, Strother, RB (2018).Vitro Magnetic Resonance Imaging Evaluation of Fragmented, Open-Coil, Percutaneous Peripheral Nerve Stimulation Leads.  Neuromodulation Volume 21, Issue 3, 276-283.
  25. Ilfeld B.M., Ball S.T., Gabriel R.A., Sztain J.F., Monahan A.M., Abramson W.B., Khatibi B., Said E.T., Parekh J., Grant S.A., Wongsarnpigoon A., Boggs J.W. 2018. A Feasibility Study of Percutaneous Peripheral Nerve Stimulation for the Treatment of Postoperative Pain Following Total Knee Arthroplasty.  Neuromodulation 2018; E-pub ahead of print.  DOI:10.1111/ner.12790
  26. Ilfeld, Brian M., et al., Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: Neuromodulation of the Sciatic Nerve for Postoperative Analgesia Following Ambulatory Foot Surgery, a Proof-of-Concept Study. Regional Anesthesia and Pain Medicine 2018. 43(6): p. 580–589.
  27. Gilmore CA, Kapural L, McGee MJ, Boggs JW. Percutaneous Peripheral Nerve Stimulation (PNS) for the Treatment of Chronic Low Back Pain Provides Sustained Relief. Neuromodulation. 2018 Oct 3. doi: 10.1111/ner.12854.
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